Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 6/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252121 | 0.89 | DAO (0.50) | DAOCDK5CDK5R1KDRF11 | |
| SCHEMBL7499608 | 0.81 | KDR (0.60) | DAOCDK5CDK5R1KDRCHEK1 | |
| SCHEMBL7503986 | 0.80 | IDH1 (0.43) | KDRIDH1CHEK1PDGFRBFGFR1 | |
| SCHEMBL7506795 | 0.79 | ALDH1A1 (0.51) | KDRPDGFRB | |
| SCHEMBL10694761 | 0.79 | KDR (0.38) | CDK5CDK5R1KDRPDGFRBFGFR1 | |
| Water SCHEMBL10691885 | 0.77 | KDM4E (0.42) | KDRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7502200 | 0.75 | KDR (0.40) | DAOCDK5CDK5R1KDRCHEK1 | |
| SCHEMBL7507967 | 0.74 | KDR (0.43) | KDR | |
| SCHEMBL7507959 | 0.74 | KDR (0.43) | KDR | |
| SCHEMBL3501686 | 0.74 | KDR (0.74) | DAOKDRCHEK1PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |