Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | DDO | Q99489 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502200 | 0.81 | KDR (0.40) | KDRPDGFRBFGFR1CHEK1DAO | |
| SCHEMBL9252121 | 0.81 | DAO (0.50) | KDRPDGFRBFGFR1CHEK1DAO | |
| SCHEMBL10691644 | 0.81 | DAO (0.50) | KDRPDGFRBFGFR1CHEK1DAO | |
| SCHEMBL10692090 | 0.78 | DAO (0.52) | KDRPDGFRBFGFR1DAO | |
| SCHEMBL10692085 | 0.78 | DAO (0.52) | KDRPDGFRBFGFR1DAOKDM4E | |
| SCHEMBL10686471 | 0.78 | KDR (0.37) | KDRPDGFRBFGFR1CHEK1DAO | |
| SCHEMBL7503986 | 0.78 | IDH1 (0.43) | KDRPDGFRBFGFR1CHEK1KDM4E | |
| Water SCHEMBL10691885 | 0.78 | KDM4E (0.42) | KDRPDGFRBFGFR1BRD4KDM4E | |
| SCHEMBL5361594 | 0.78 | RAB9A (0.50) | KDRCHEK1KDM4ENPC1ALDH1A1 | |
| SCHEMBL7502994 | 0.77 | DAO (0.41) | KDRPDGFRBFGFR1CHEK1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | claimed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | claimed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | claimed |
| EP-0905133-B1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0905133-A1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO. LTD. (JP) | 1999-03-31 | — | — | EP | disclosed |
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |