Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | NCK1 | P16333 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 5/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629582 | 0.84 | PIK3CG (0.48) | BACE1PIK3CGFGFR3KDRHTR3E | |
| SCHEMBL15551629 | 0.83 | ALDH1A1 (0.45) | PIK3CGFGFR3KDR | |
| SCHEMBL2479182 | 0.79 | PLAU (0.52) | BACE1PLAUNCK1NCF1NOS2 | |
| SCHEMBL31119356 | 0.79 | PLAU (0.52) | BACE1PLAUNCK1NCF1NOS2 | |
| SCHEMBL14984944 | 0.76 | FGFR3 (0.40) | FGFR3KDR | |
| SCHEMBL1932280 | 0.76 | BACE1 (0.57) | BACE1PLAUNCK1NCF1NOS2 | |
| SCHEMBL15690411 | 0.76 | BACE1 (0.55) | BACE1PLAUNCK1NCF1NOS2 | |
| SCHEMBL4725394 | 0.76 | PIK3CG (0.53) | BACE1TECPIK3CGHTR3EHTR3B | |
| SCHEMBL15715216 | 0.76 | CYP1A2 (0.44) | FGFR3KDR | |
| SCHEMBL16735797 | 0.76 | NR4A2 (0.51) | BACE1TECPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4720500-A | N-1,8-naphthyridin-2-yl amides useful as immunostimulants | RHONE-POULENC SANTE (FR) | 1988-01-19 | — | — | US | disclosed |
| US-4016274-A | TRANQUILIZERS AND ANTICONVULSANT AGENTS | RHONE-POULENC S.A. (FR) | 1977-04-05 | — | — | US | disclosed |