Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1831403 | 0.84 | SLC6A2 (0.56) | HAO1SLC6A2SLC6A4 | |
| SCHEMBL15235893 | 0.83 | ALDH1A1 (0.55) | MAPTPKMALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL6082774 | 0.83 | ALDH1A1 (0.55) | MAPTPKMALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL15977387 | 0.83 | ALDH1A1 (0.55) | MAPTPKMALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL28600953 | 0.82 | MAPT (0.47) | MAPTPKMALDH1A1SMN1; SMN2ESR2 | |
| SCHEMBL14244289 | 0.82 | MAPT (0.47) | MAPTPKMALDH1A1SMN1; SMN2ESR2 | |
| SCHEMBL15428491 | 0.82 | MAPT (0.47) | MAPTPKMALDH1A1SMN1; SMN2ESR2 | |
| SCHEMBL433974 | 0.82 | MAPT (0.47) | MAPTPKMALDH1A1SMN1; SMN2ESR2 | |
| SCHEMBL28386076 | 0.82 | MAPT (0.41) | MAPTPKMPDE4APDE4BPDE4C | |
| SCHEMBL4140532 | 0.81 | SLC9A1 (0.50) | MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251466-A2 | Chemical process for the preparation of esters of substituted cyclopropyl caboxylic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-01-07 | — | — | EP | disclosed |