Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoperazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | SLC22A6 | Q4U2R8 | 4/20 | 0.71 |
| ▸ | SLC22A8 | Q8TCC7 | 4/20 | 0.71 |
| ▸ | SLC22A11 | Q9NSA0 | 4/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.66 |
| ▸ | PGR | P06401 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.64 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL28086380 | 0.95 | MAPT (0.75) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL1832806 | 0.93 | MAPT (0.72) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL16093919 | 0.92 | MAPT (0.71) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL22532797 | 0.87 | MAPT (0.73) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Piperacillin SCHEMBL6271736 | 0.87 | NR1I2 (0.54) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL28256039 | 0.86 | MAPT (0.61) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL1963141 | 0.85 | TDP1 (0.65) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL27651465 | 0.85 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL40452 | 0.85 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL18061225 | 0.84 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0256713-A2 | Therapeutic human antipseudomonas aeruginosa antibodies | MERCK & CO. INC. (US) | 1988-02-24 | — | — | EP | disclosed |