Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoperazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.99 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.99 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.99 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.99 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.99 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.98 |
| ▸ | THRB | P10828 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.87 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL27651465 | 1.00 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL16091123 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL37056 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL11522109 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL2222952 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL16072819 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL9326569 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL18061225 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL15387468 | 0.99 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL3758644 | 0.99 | HSD17B10 (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4233 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117482095-B | Cefoperazone sodium and sulbactam sodium composition and preparation method thereof | CHENGDU JINGFU PHARMACEUTICAL TECHNOLOGY Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2025111413-A1 | TREATMENT FOR SKIN DISORDERS | Mycotechnology, Inc. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119818504-A | Antibacterial composition of cefoperazone and avibactam and application thereof | 重庆圣华曦药业股份有限公司 | 2025-04-15 | — | — | CN | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-119391643-B | Culture medium and method for culturing digestive tract tumor by using three-dimensional tumor tablet technology | 珠海澳大科技研究院 | 2025-03-14 | — | — | CN | claimed |
| CN-115684393-B | Two-dimensional detection method for impurities in cefoperazone sodium and sulbactam sodium for injection | 北京悦康科创医药科技股份有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-119438454-A | Cefoperazone sodium sulbactam sodium polymer for injection and specific impurity analysis method | 哈药集团技术中心 | 2025-02-14 | — | — | CN | claimed |
| CN-119438417-A | Method for detecting polymer in cefoperazone sodium and sulbactam sodium | 海南卫康制药(潜山)有限公司 | 2025-02-14 | — | — | CN | claimed |
| CN-119391643-A | Culture medium and method for culturing digestive tract tumor by using three-dimensional tumor tablet technology | 珠海澳大科技研究院 | 2025-02-07 | — | — | CN | claimed |
| CN-222117262-U | Sealed filling mechanism of cefoperazone sodium and sulbactam sodium | 山西振东泰盛制药有限公司 | 2024-12-06 | — | — | CN | claimed |
| WO-2002030469-A2 | BETA-LACTAM ANTIBIOTIC-POLYSACCHARIDE COMPLEX | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2002-04-18 | — | — | WO | claimed |
| WO-2001079210-A2 | A PROCESS FOR THE PREPARATION OF HIGHLY CRYSTALLINE SODIUM CEFOPERAZONE | ANTIBIOTICOS S.P.A. (IT) | 2001-10-25 | — | — | WO | claimed |
| US-6245735-B1 | CONJUGATE OF ANTIBIOTIC AND POLYPEPTIDE OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR OR LIPOPOLYSACCHARIDE BINDING FRAGMENT | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2001-06-12 | — | — | US | claimed |
| US-4678512-A | Marine coating compositions and method | GRAMS RALPH R | 1987-07-07 | — | — | US | claimed |
| EP-0118196-B1 | PROCESS FOR THE MANUFACTURE OF HIGHLY CRYSTALLINE SODIUM CEFOPERAZONE | PFIZER INC. (US) | 1986-12-30 | — | — | EP | claimed |
| EP-0101170-B1 | PROCESS FOR THE MANUFACTURE OF SODIUM CEFOPERAZONE | PFIZER INC. (US) | 1986-01-15 | — | — | EP | claimed |
| EP-0118196-A1 | Process for the manufacture of highly crystalline sodium cefoperazone | PFIZER INC. (US) | 1984-09-12 | — | — | EP | claimed |
| US-4458070-A | Process for the manufacture of crystalline sodium cefoperazone | PFIZER INC. (US) | 1984-07-03 | — | — | US | claimed |
| US-4456753-A | Process for the manufacture of highly crystalline sodium cefoperazone | PFIZER INC. (US) | 1984-06-26 | — | — | US | claimed |
| EP-0101170-A1 | Process for the manufacture of sodium cefoperazone | PFIZER INC. (US) | 1984-02-22 | — | — | EP | claimed |