Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 15/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 15/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694129 | 0.93 | LTB4R (0.46) | LTB4RLTB4R2BRD4KDM4EALDH1A1 | |
| SCHEMBL10344475 | 0.92 | LTB4R (0.44) | LTB4RLTB4R2BRD4KDM4EALDH1A1 | |
| SCHEMBL10344389 | 0.87 | CYSLTR2 (0.47) | LTB4RLTB4R2 | |
| SCHEMBL10344328 | 0.85 | LTB4R (0.40) | LTB4RLTB4R2KDM4EALDH1A1GAA | |
| SCHEMBL10689515 | 0.84 | LTB4R (0.41) | LTB4RLTB4R2KDM4EALDH1A1GAA | |
| SCHEMBL10344546 | 0.84 | LTB4R (0.41) | LTB4RLTB4R2KDM4EALDH1A1GAA | |
| SCHEMBL10344387 | 0.79 | BRD4 (0.49) | BRD4KDM4EALDH1A1GAAHPGD | |
| SCHEMBL9513132 | 0.79 | LTB4R (0.51) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9515370 | 0.79 | LTB4R (0.51) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9513714 | 0.79 | LTB4R (0.51) | LTB4RLTB4R2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261254-A1 | 3,4-Dihydro-4-oxo-2H-1-benzopyranyloxy alkanoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-30 | — | — | EP | disclosed |
| US-4650812-A | ANTIALLERGY | HOFFMANN-LA ROCHE INC. (US) | 1987-03-17 | — | — | US | disclosed |