Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695261 | 0.92 | BRD4 (0.50) | BRD4KDM4EALDH1A1HPGDGAA | |
| SCHEMBL10704709 | 0.83 | MEN1 (0.43) | BRD4KDM4EALDH1A1HPGDGAA | |
| SCHEMBL10694125 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL10689874 | 0.80 | CYSLTR1 (0.49) | — | |
| SCHEMBL10344312 | 0.80 | MAOB (0.46) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL10692495 | 0.79 | LTB4R (0.44) | BRD4KDM4EALDH1A1HPGDGAA | |
| SCHEMBL9635631 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL9512184 | 0.76 | KDM4E (0.46) | BRD4KDM4EALDH1A1HPGDGAA | |
| SCHEMBL10691900 | 0.74 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDGAACASP1 | |
| SCHEMBL22578031 | 0.74 | BRD4 (0.65) | BRD4ALDH1A1HPGDMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261254-B1 | 3,4-DIHYDRO-4-OXO-2H-1-BENZOPYRANYLOXY ALKANOIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-02-07 | — | — | EP | disclosed |
| EP-0261254-A1 | 3,4-Dihydro-4-oxo-2H-1-benzopyranyloxy alkanoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-30 | — | — | EP | disclosed |
| US-4650812-A | ANTIALLERGY | HOFFMANN-LA ROCHE INC. (US) | 1987-03-17 | — | — | US | disclosed |