Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 12/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tibenelast SCHEMBL449748 | 0.86 | STING1 (0.54) | STING1TSHR | |
| Tibenelast SCHEMBL635433 | 0.84 | STING1 (0.53) | STING1TSHR | |
| Tibenelast SCHEMBL10688452 | 0.84 | STING1 (0.53) | STING1TSHR | |
| SCHEMBL10688443 | 0.84 | STING1 (0.53) | STING1TSHRHDAC3HDAC4HDAC1 | |
| Tibenelast SCHEMBL635432 | 0.83 | STING1 (0.49) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7106760 | 0.82 | STING1 (0.61) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10641965 | 0.81 | STING1 (0.60) | STING1 | |
| SCHEMBL10691807 | 0.81 | HPGD (0.53) | STING1TSHRHDAC3HDAC4HDAC1 | |
| SCHEMBL10642176 | 0.81 | STING1 (0.60) | STING1 | |
| SCHEMBL10537567 | 0.80 | STING1 (0.49) | STING1TSHRCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253650-A2 | Improvements relating to benzothiophene derivatives | ELI LILLY AND COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |