Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575026 | 0.94 | MAPT (0.58) | MAPTHDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL10574313 | 0.89 | HDAC6 (0.56) | MAPTHDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL10571602 | 0.86 | LMNA (0.60) | MAPTHDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL10571732 | 0.85 | LMNA (0.51) | HDAC6HDAC1HDAC8HDAC5SMN1; SMN2 | |
| SCHEMBL10571411 | 0.85 | LMNA (0.51) | HDAC6HDAC1HDAC8HDAC5SMN1; SMN2 | |
| SCHEMBL10523492 | 0.85 | LMNA (0.51) | HDAC6HDAC1HDAC8HDAC5SMN1; SMN2 | |
| SCHEMBL10572076 | 0.82 | ALDH1A1 (0.54) | HDAC6HDAC1HDAC8HDAC5TSHR | |
| SCHEMBL10570931 | 0.82 | CYP19A1 (0.46) | HDAC6HDAC1HDAC8HDAC5ESR1 | |
| SCHEMBL10571455 | 0.79 | LMNA (0.58) | MAPTHDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL3739324 | 0.79 | HDAC6 (0.54) | HDAC6HDAC1HDAC8HDAC5TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-87107226-A | Lactam derivatives and preparation thereof | — | 1988-06-29 | — | — | CN | claimed |
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | claimed |