Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377659 | 0.82 | ACHE (0.38) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL10378822 | 0.79 | PARP1 (0.47) | ACHEBCHEGRIN1GRIN2APLAU | |
| SCHEMBL10377744 | 0.78 | KDM4E (0.39) | ACHEBCHEGRIN1GRIN2ACYP1A2 | |
| SCHEMBL10688754 | 0.76 | KDM4E (0.37) | ACHEHTTMAPTMAP4K1 | |
| SCHEMBL10685831 | 0.75 | CYP19A1 (0.35) | CSNK2A1DYRK1AMAPTFLT3AHR | |
| SCHEMBL10379456 | 0.73 | KMT2A (0.38) | ACHEBCHEGRIN1GRIN2AMAP4K1 | |
| SCHEMBL10379440 | 0.73 | ACHE (0.38) | ACHEBCHEGRIN1GRIN2ANOS1 | |
| SCHEMBL10687008 | 0.73 | ACHE (0.38) | ACHEBCHEGRIN1GRIN2AMAP4K1 | |
| SCHEMBL19629535 | 0.69 | KDM4E (0.42) | PLAUNCF1NOS1CYP1A2 | |
| SCHEMBL21828348 | 0.67 | MAP4K1 (0.36) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | claimed |
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |