Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.38 |
| ▸ | BCHE | P06276 | 7/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379456 | 0.82 | KMT2A (0.38) | ACHEBCHEGRIN1GRIN2AMAP4K1 | |
| SCHEMBL10379440 | 0.82 | ACHE (0.38) | ACHEBCHEGRIN1GRIN2APOLB | |
| SCHEMBL10377744 | 0.78 | KDM4E (0.39) | ACHEBCHEGRIN1GRIN2AMAP4K1 | |
| SCHEMBL10688754 | 0.76 | KDM4E (0.37) | ACHEMAP4K1HSD17B10ALOX12TDP1 | |
| SCHEMBL10688708 | 0.75 | LMNA (0.36) | ACHEHSD17B10ALDH1A1 | |
| SCHEMBL10692924 | 0.73 | ACHE (0.38) | ACHEBCHEGRIN1GRIN2AMAP4K1 | |
| SCHEMBL10377659 | 0.73 | ACHE (0.38) | ACHEBCHEGRIN1GRIN2APOLB | |
| SCHEMBL10378822 | 0.73 | PARP1 (0.47) | ACHEBCHEGRIN1GRIN2AHSD17B10 | |
| SCHEMBL22884698 | 0.69 | MAP4K1 (0.38) | MAP4K1UHRF1HSD17B10ALOX12TDP1 | |
| SCHEMBL19629535 | 0.69 | KDM4E (0.42) | HSD17B10TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | claimed |
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |