Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789401 | 0.79 | POLB (0.44) | POLBALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL15022582 | 0.77 | ALOX15 (0.41) | POLBALDH1A1CYP1A2KDM4ESMN1; SMN2 | |
| SCHEMBL27341760 | 0.76 | CYP1A2 (0.64) | POLBALDH1A1CYP1A2CYP2C19KDM4E | |
| SCHEMBL4351790 | 0.75 | POLB (0.53) | POLBALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL31109181 | 0.73 | SMN1; SMN2 (0.52) | POLBALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL28674515 | 0.73 | PLK1 (0.44) | POLBALDH1A1CYP1A2CYP2C19KDM4E | |
| SCHEMBL31109177 | 0.73 | SMN1; SMN2 (0.52) | POLBALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL27693524 | 0.72 | KMT2A (0.54) | POLBALDH1A1CYP2C19KDM4EALOX15 | |
| SCHEMBL394571 | 0.72 | POLB (0.58) | POLBALDH1A1KDM4EALOX15MAPT | |
| SCHEMBL5717618 | 0.72 | ALDH1A1 (0.67) | POLBALDH1A1KDM4ESMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259838-A2 | Pharmaceutical composition containing A 1,4-dihydropyridine derivative and an acylated 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | SYNTEX (U.S.A.) INC. (US) | 1988-03-16 | — | — | EP | disclosed |