Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692481 | 0.86 | TSHR (0.49) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL10694845 | 0.82 | L3MBTL1 (0.51) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1747808 | 0.78 | TSHR (0.52) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7601879 | 0.77 | TSHR (0.55) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21138360 | 0.77 | TSHR (0.55) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL10985089 | 0.76 | ALDH1A1 (0.72) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1684895 | 0.76 | — | — | |
| SCHEMBL5986980 | 0.76 | TSHR (0.53) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL895343 | 0.76 | L3MBTL1 (0.55) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL12086321 | 0.74 | TSHR (0.52) | TSHRL3MBTL1ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735944-A | CAPBOCYCLIC RING CONTAINING NITROGEN | SANDOZ LTD. (CH) | 1988-04-05 | — | — | US | disclosed |