Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695479 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1ADORA3ADORA2AADORA1 | |
| SCHEMBL10699106 | 0.85 | ALDH1A1 (0.40) | KDM4EALDH1A1HSD17B10ADORA3ADORA2A | |
| SCHEMBL10695734 | 0.84 | TNKS2 (0.48) | KDM4EALDH1A1HPGDTDP1KMT2A | |
| SCHEMBL10696186 | 0.84 | KMT2A (0.43) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL10698144 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1HSD17B10HPGDTDP1 | |
| SCHEMBL10700676 | 0.82 | ALDH1A1 (0.38) | KDM4EALDH1A1HSD17B10TDP1KMT2A | |
| SCHEMBL10696066 | 0.78 | ALDH1A1 (0.38) | KDM4EALDH1A1HSD17B10ADORA3ADORA2A | |
| SCHEMBL10695498 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1HSD17B10HPGDTDP1 | |
| SCHEMBL10696064 | 0.72 | MEN1 (0.47) | KDM4EALDH1A1HSD17B10ROCK2HPGD | |
| SCHEMBL10699328 | 0.71 | KDM4E (0.41) | KDM4EALDH1A1ADORA3HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |