Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946506 | 0.89 | MAPT (0.55) | KMT2AMAPTSCN5ASCN9ALMNA | |
| SCHEMBL3837958 | 0.89 | MAPT (0.55) | KMT2AMAPTSCN5ASCN9ALMNA | |
| SCHEMBL13946510 | 0.89 | MAPT (0.55) | KMT2AMAPTSCN5ASCN9ALMNA | |
| Benzoic Acid SCHEMBL30973625 | 0.81 | TSHR (0.48) | KMT2AMAPTSCN5ASCN9AMEN1 | |
| SCHEMBL19205720 | 0.79 | SCN5A (0.54) | KMT2AMAPTSCN5ASCN9ALMNA | |
| Piperazine SCHEMBL10994605 | 0.76 | KMT2A (0.39) | KMT2AMAPTLMNACYP2D6MEN1 | |
| SCHEMBL6264368 | 0.76 | SCN5A (0.62) | KMT2AMAPTSCN5ASCN9ALMNA | |
| SCHEMBL10694182 | 0.75 | CHRM2 (0.57) | KMT2AMAPTLMNACYP2D6MEN1 | |
| SCHEMBL6258957 | 0.75 | SCN5A (0.69) | KMT2AMAPTSCN5ASCN9ALMNA | |
| SCHEMBL4558669 | 0.74 | CHRM3 (0.41) | KMT2AMAPTMEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | disclosed |