Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25060954 | 0.75 | SMN1; SMN2 (0.60) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10391047 | 0.75 | POLB (0.76) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10389914 | 0.74 | SMN1; SMN2 (0.71) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14134481 | 0.73 | L3MBTL1 (0.63) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5806164 | 0.73 | TDP1 (0.54) | POLBGAASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL11629762 | 0.72 | ALDH1A1 (0.56) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11626357 | 0.72 | SMN1; SMN2 (0.57) | POLBSMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL11642806 | 0.72 | POLB (0.54) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10389609 | 0.72 | ALDH1A1 (0.50) | POLBGAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10389641 | 0.70 | ALDH1A1 (0.47) | POLBGAASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4767765-A | ANXIOLYTIC OR ANTIEPILEPTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0223974-A1 | N-Substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-phenyl]alkanamides, carbamates and ureas | AMERICAN CYANAMID COMPANY (US) | 1987-06-03 | — | — | EP | disclosed |
| US-4654343-A | USEFUL AS ANXIOLYTIC OR ANTIEPILEPTIC AGENTS AS WELL AS SEDATIVE-HYPNOTIC AND SKELETAL MUSCLE RELAXANT AGENTS | AMERICAN CYANAMID COMPANY (US) | 1987-03-31 | — | — | US | disclosed |