Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.56 |
| ▸ | GSK3B | P49841 | 12/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114611 | 0.84 | PTGS2 (0.67) | PTGS2GSK3B | |
| SCHEMBL9474080 | 0.81 | PTGS2 (0.64) | PTGS2GSK3B | |
| SCHEMBL5060968 | 0.79 | PTGS2 (0.40) | PTGS2GSK3BALDH1A1HSD17B10 | |
| SCHEMBL187764 | 0.78 | PTGS2 (0.61) | PTGS2GSK3B | |
| SCHEMBL18049412 | 0.78 | PTGS2 (0.59) | PTGS2GSK3B | |
| SCHEMBL11270084 | 0.75 | PTGS2 (0.61) | PTGS2GSK3B | |
| SCHEMBL29042770 | 0.75 | KIF11 (0.42) | PTGS2 | |
| SCHEMBL94149 | 0.74 | GSK3B (0.58) | PTGS2GSK3B | |
| SCHEMBL22144497 | 0.74 | GSK3B (0.53) | PTGS2GSK3B | |
| SCHEMBL3164032 | 0.74 | PTGS2 (0.55) | PTGS2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948177-A1 | METHODS FOR OPTIMIZING DOMAIN STABILITY OF BINDING PROTEINS | AbbVie Inc. (US) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014116596-A1 | METHODS FOR OPTIMIZING DOMAIN STABILITY OF BINDING PROTEINS | ABBVIE, INC. (US) | 2014-07-31 | — | — | WO | disclosed |
| US-4735792-A | PROTEIN BINDERS; MEDICAL DIAGNOSIS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 1988-04-05 | — | — | US | disclosed |