Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | STK3 | Q13188 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382675 | 0.80 | SYK (0.46) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL4382681 | 0.80 | SYK (0.46) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL1070139 | 0.80 | SYK (0.49) | SYKCDK2JAK3JAK2TYK2 | |
| SCHEMBL1069491 | 0.80 | SYK (0.44) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL12082662 | 0.78 | JAK2 (0.43) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL1073636 | 0.76 | SYK (0.47) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL1017367 | 0.71 | SYK (0.51) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL1019485 | 0.69 | ULK1 (0.52) | SYKJAK3JAK2TYK2 | |
| SCHEMBL1069930 | 0.68 | SYK (0.49) | SYKPDGFRBPDGFRACDC7WEE1 | |
| SCHEMBL1018050 | 0.68 | JAK3 (0.53) | FLT3JAK3JAK2LCKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |