Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.68 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | PKM | P14618 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969101 | 0.82 | NPC1 (0.69) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL29855452 | 0.82 | NPC1 (0.69) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL19064366 | 0.82 | NPC1 (0.69) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL3335441 | 0.81 | NPC1 (1.00) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL2415345 | 0.81 | NPC1 (1.00) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL3054720 | 0.81 | NPC1 (0.68) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL12402878 | 0.81 | NPC1 (0.68) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL29386825 | 0.80 | NPC1 (0.88) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL2178266 | 0.80 | NPC1 (0.88) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL3059386 | 0.80 | ATR (0.73) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |