Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13341484 | 0.88 | SLC2A1 (0.47) | TDP1ADAMTS5MMP12SLC2A1NPC1 | |
| SCHEMBL13341497 | 0.88 | AURKA (0.49) | TDP1ADAMTS5SLC2A1NPC1RAB9A | |
| SCHEMBL13341504 | 0.88 | AURKA (0.48) | TDP1SLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10694210 | 0.87 | PDE4A (0.51) | TDP1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL10701197 | 0.87 | AURKA (0.57) | SLC2A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10700220 | 0.85 | SLC2A1 (0.46) | SLC2A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10700270 | 0.85 | AURKA (0.47) | SLC2A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10695078 | 0.84 | AURKA (0.46) | SLC2A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13341470 | 0.84 | SLC2A1 (0.45) | SLC2A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13341249 | 0.83 | AURKA (0.62) | SLC2A1NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |