Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28281 | 0.83 | — | — | |
| SCHEMBL28765706 | 0.83 | GNAO1 (0.41) | GABRA5GABRA1LMNACYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL1652678 | 0.81 | GBA1 (0.40) | GABRA5GABRA1GNAO1GNAI3GNAI1 | |
| SCHEMBL28134700 | 0.81 | — | — | |
| Propionic Acid SCHEMBL27304995 | 0.81 | GABRA5 (0.46) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| Acetic Acid SCHEMBL5764925 | 0.80 | GABRA5 (0.44) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL28134699 | 0.79 | — | — | |
| Oxalic Acid SCHEMBL9344093 | 0.78 | GABRA5 (0.45) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL2169002 | 0.78 | GABRA5 (0.46) | GABRA5GABRA1LMNACYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL29891111 | 0.76 | GABRA5 (0.45) | GABRA5GABRA1LMNACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |
| EP-0266880-A2 | Hybridomas and monoclonal paratopic molecules to apolipoprotein A-I | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1988-05-11 | — | — | EP | disclosed |