Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693610 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL28345176 | 0.78 | KDM4E (0.46) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL10696374 | 0.78 | KDM4E (0.49) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL10695218 | 0.77 | ELANE (0.40) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL9770643 | 0.77 | ELANE (0.39) | KDM4ESMN1; SMN2HSD17B10HPGDALDH1A1 | |
| SCHEMBL28345238 | 0.75 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL31396718 | 0.73 | NPC1 (0.60) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL18337434 | 0.73 | NPC1 (0.60) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL6704339 | 0.71 | KDM4E (0.54) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL28883171 | 0.70 | KDM4E (0.61) | KDM4ESMN1; SMN2NPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |