Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
| ▸ | GUSB | P08236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701072 | 0.83 | AURKA (0.59) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10698460 | 0.80 | AURKA (0.48) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10695935 | 0.80 | AURKA (0.48) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10698186 | 0.79 | PDE4A (0.40) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10699199 | 0.78 | MAPT (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6454096 | 0.75 | NPC1 (0.47) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL4827138 | 0.74 | AURKA (0.40) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL5618911 | 0.74 | AURKA (0.50) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL4886259 | 0.73 | FGFR1 (0.48) | AURKAAURKBALDH1A1 | |
| SCHEMBL4946021 | 0.73 | AURKA (0.39) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |