Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | DHFR | P00374 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14544359 | 0.88 | DHFR (0.56) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| SCHEMBL11946661 | 0.86 | TSHR (0.54) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL28122264 | 0.79 | SMN1; SMN2 (1.00) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL40863 | 0.79 | SMN1; SMN2 (1.00) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL29207414 | 0.77 | SMN1; SMN2 (0.96) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL16097762 | 0.77 | SMN1; SMN2 (0.96) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL23317 | 0.77 | SMN1; SMN2 (0.96) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL2503539 | 0.77 | SMN1; SMN2 (0.96) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL3912378 | 0.77 | SMN1; SMN2 (0.96) | TSHRDHFRSMN1; SMN2TDP1PKM | |
| Sulfacetamide SCHEMBL28182511 | 0.77 | SMN1; SMN2 (0.96) | TSHRDHFRSMN1; SMN2TDP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255100-A2 | Use of trimetrexate and its salts for the preparation of pharmaceutical compositions for treating infections of the mycobacterium-avium-intracellulare complex | WARNER-LAMBERT COMPANY (US) | 1988-02-03 | — | — | EP | claimed |
| EP-4382109-A1 | USE OF A COMPOSITE MATERIAL | Heraeus Medical GmbH (DE) | 2024-06-12 | — | — | EP | disclosed |