Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518423 | 1.00 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL1518424 | 1.00 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL2028913 | 0.88 | REN (0.71) | RENKCNH2CYP3A4 | |
| SCHEMBL2028911 | 0.88 | REN (0.71) | RENKCNH2CYP3A4 | |
| SCHEMBL1071479 | 0.87 | REN (0.52) | RENKCNH2CYP3A4 | |
| SCHEMBL1071478 | 0.87 | REN (0.52) | RENKCNH2CYP3A4 | |
| SCHEMBL1072238 | 0.82 | REN (0.70) | RENKCNH2CYP3A4 | |
| SCHEMBL1072237 | 0.82 | REN (0.70) | RENKCNH2CYP3A4 | |
| SCHEMBL4325735 | 0.82 | REN (0.50) | RENKCNH2CYP3A4 | |
| SCHEMBL1518196 | 0.82 | REN (1.00) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274295-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |