Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028911 | 1.00 | REN (0.71) | RENKCNH2CYP3A4SGMS1SGMS2 | |
| SCHEMBL1518423 | 0.88 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL1069755 | 0.88 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL1518424 | 0.88 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL1071478 | 0.84 | REN (0.52) | RENKCNH2CYP3A4 | |
| SCHEMBL1071479 | 0.84 | REN (0.52) | RENKCNH2CYP3A4 | |
| SCHEMBL12584253 | 0.83 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL2028370 | 0.83 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL2028367 | 0.83 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL2028372 | 0.83 | REN (1.00) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152316-A1 | 3,4-SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152316-A1 | 3,4-SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885KCNH2 585/4885CYP3A4 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.