Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194437 | 0.80 | DPP4 (0.58) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL28811341 | 0.79 | DPP4 (0.42) | TDP1ALDH1A1DPP4LMNANOS3 | |
| SCHEMBL29655079 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL29655203 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL27864754 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL10714748 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL719169 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL29655290 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL28258156 | 0.79 | TDP1 (0.64) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL16816932 | 0.78 | TDP1 (0.62) | TDP1MAPTMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |