Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27480430 | 0.85 | ALDH1A1 (0.46) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL29655290 | 0.81 | TDP1 (0.64) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL28258156 | 0.81 | TDP1 (0.64) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL29655079 | 0.81 | TDP1 (0.64) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL27864754 | 0.81 | TDP1 (0.64) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL10714748 | 0.81 | TDP1 (0.64) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL719169 | 0.81 | TDP1 (0.64) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL16816932 | 0.80 | TDP1 (0.62) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL29409289 | 0.79 | MAPT (1.00) | TDP1MAPTMEN1KMT2APOLB | |
| SCHEMBL737722 | 0.79 | MAPT (1.00) | TDP1MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |