Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29745294 | 0.80 | PDE5A (0.60) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL10696479 | 0.80 | PDE5A (0.60) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL10695892 | 0.76 | PDE5A (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL10695856 | 0.75 | PDE5A (0.61) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL23122458 | 0.75 | AURKA (0.58) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL11584027 | 0.75 | HCAR2 (0.61) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL27678090 | 0.73 | AURKA (0.56) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL31499116 | 0.69 | NUDT1 (0.51) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL24520478 | 0.69 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL1170747 | 0.68 | METAP1 (0.72) | NUDT1METAP1METAP2PDE5AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254588-A1 | Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same | TOKYO TANABE COMPANY LIMITED (JP) | 1988-01-27 | — | — | EP | claimed |