Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.60 |
| ▸ | PDE4A | P27815 | 5/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.60 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29745294 | 0.88 | PDE5A (0.60) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10696479 | 0.88 | PDE5A (0.60) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23122458 | 0.80 | AURKA (0.58) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10695856 | 0.79 | PDE5A (0.61) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27678090 | 0.78 | AURKA (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3974150 | 0.77 | RAB9A (0.53) | KMT2AHPGD | |
| SCHEMBL10697822 | 0.76 | NUDT1 (0.47) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3960231 | 0.73 | CYP2C9 (0.57) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2314765 | 0.73 | DDAH1 (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9164427 | 0.72 | GABRP (0.37) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254588-A1 | Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same | TOKYO TANABE COMPANY LIMITED (JP) | 1988-01-27 | — | — | EP | claimed |