Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697870 | 1.00 | HDAC8 (0.47) | HDAC8THRBATMPTGER4PTGER2 | |
| SCHEMBL9650615 | 0.87 | PTGER4 (0.53) | PTGER4PTGER2KDM4ELMNAPTGER1 | |
| SCHEMBL9650626 | 0.87 | PTGER4 (0.53) | PTGER4PTGER2KDM4ELMNAPTGER1 | |
| SCHEMBL9366663 | 0.83 | NPC1 (0.48) | HDAC8NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL9741507 | 0.80 | RAB9A (0.51) | HDAC8NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL2438835 | 0.78 | NPC1 (0.50) | HDAC8NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL3601000 | 0.76 | FFAR1 (0.57) | NPC1POLBRAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL3600996 | 0.76 | POLB (0.44) | HDAC8NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL106114 | 0.76 | NPC1 (0.43) | HDAC8NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL104633 | 0.74 | MTNR1A (0.42) | HDAC8NPC1POLBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265185-A2 | Cephalosporins, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-04-27 | — | — | EP | disclosed |