Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 5/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697738 | 0.90 | SCD (0.42) | ALDH1A1HPGDHSD17B10SCDGUSB | |
| SCHEMBL10699100 | 0.88 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL10701672 | 0.88 | MAPT (0.48) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL10700668 | 0.88 | PDE4A (0.41) | KDM4EALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL10699596 | 0.87 | SLC2A1 (0.46) | KDM4EALDH1A1HPGDPDE3BPDE3A | |
| SCHEMBL10694143 | 0.85 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL10700922 | 0.83 | CBFB (0.52) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL10532367 | 0.81 | PDE4A (0.41) | KDM4EALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL10698622 | 0.79 | SCD (0.40) | KDM4EALDH1A1HPGDHSD17B10RHEB | |
| SCHEMBL10698629 | 0.79 | SCD (0.43) | ALDH1A1HPGDHSD17B10SCDGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |