Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 2/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697738 | 0.89 | SCD (0.42) | SCDGUSBNPBWR1TOP1TOP2A | |
| SCHEMBL10699100 | 0.88 | ALDH1A1 (0.45) | SCDGUSBALDH1A1HPGDHSD17B10 | |
| SCHEMBL10698622 | 0.87 | SCD (0.40) | SCDGUSBNPBWR1TOP1TOP2A | |
| SCHEMBL10696182 | 0.85 | SCD (0.46) | SCDGUSBNPBWR1TOP1TOP2A | |
| SCHEMBL10699321 | 0.82 | HPGD (0.51) | GUSBALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10532530 | 0.80 | GUSB (0.43) | SCDGUSBNPBWR1TOP1TOP2A | |
| SCHEMBL10698129 | 0.79 | KDM4E (0.43) | SCDGUSBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10698880 | 0.79 | CBFB (0.51) | ALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10699596 | 0.79 | SLC2A1 (0.46) | GUSBNPBWR1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10699429 | 0.77 | TOP1 (0.45) | SCDGUSBNPBWR1TOP1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |