Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | GCGR | P47871 | 3/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973118 | 0.78 | PTGS2 (0.39) | PTGS2MAPK14GCGR | |
| SCHEMBL10993716 | 0.77 | MAPK14 (0.78) | PTGS2MAPK14GCGRNR4A2MAPK1 | |
| SCHEMBL27892713 | 0.74 | MAPK14 (0.52) | MAPK14GCGRDYRK1AMAPK1 | |
| SCHEMBL5366395 | 0.74 | CYP2A6 (0.45) | PTGS2 | |
| SCHEMBL1560587 | 0.72 | PTGS2 (0.41) | PTGS2MAPK14GCGRPOLB | |
| SCHEMBL10733900 | 0.71 | PTGS2 (1.00) | PTGS2MAPK14GCGRTDO2 | |
| SCHEMBL7971869 | 0.71 | PTGS2 (1.00) | PTGS2MAPK14GCGRTDO2 | |
| SCHEMBL22082710 | 0.71 | MAPK14 (0.48) | PTGS2MAPK14GCGRACHEMAPK1 | |
| SCHEMBL2285019 | 0.71 | MAPK14 (0.68) | PTGS2MAPK14GCGRNR4A2 | |
| SCHEMBL10971724 | 0.70 | MAPK14 (0.60) | PTGS2MAPK14GCGRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265640-A2 | Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals | SANDOZ AG (CH) | 1988-05-04 | — | — | EP | disclosed |