Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.57 |
| ▸ | GCGR | P47871 | 1/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | TDO2 | P48775 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10733900 | 1.00 | PTGS2 (1.00) | PTGS2MAPK14GCGRMAPK13RAF1 | |
| SCHEMBL27504944 | 0.83 | PTGS2 (0.70) | PTGS2MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL10993716 | 0.82 | MAPK14 (0.78) | PTGS2MAPK14GCGRMAPK13RAF1 | |
| SCHEMBL8095456 | 0.80 | PTGS2 (0.67) | PTGS2MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL6470141 | 0.78 | PTGS2 (0.74) | PTGS2 | |
| SCHEMBL7395459 | 0.78 | PTGS2 (0.74) | PTGS2 | |
| SCHEMBL215130 | 0.78 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL7981809 | 0.77 | PTGS2 (0.77) | PTGS2MAPK14GCGRMAPK13RAF1 | |
| SCHEMBL10740403 | 0.77 | PTGS2 (1.00) | PTGS2MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL444872 | 0.76 | PTGS2 (0.69) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294568-B1 | ANTIINFLAMMATORY AGENTS AND ANTITUMOR AGENTS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENTS AND COX2 ENZYME INHIBITORS | NISSIN FOOD PRODUCTS CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-1048649-A1 | 5-ARYLPYRROLE DERIVATIVES | NISSIN FOOD PRODUCTS CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-4652582-A | ANALGESICS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0034798-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-(SUBSTITUTED-THIO)PYRROLES AND THEIR CORRESPONDING SULFOXIDES AND SULFONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |
| EP-0034798-A2 | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-09-02 | — | — | EP | disclosed |