Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 4/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10408027 | 1.00 | ALDH1A1 (0.37) | ALDH1A1HPGDHSD17B2F2PRSS1 | |
| SCHEMBL10698420 | 0.77 | PPIA (0.52) | ALDH1A1PTGDR2ESR1ESR2POLB | |
| SCHEMBL10698583 | 0.74 | PPIA (0.49) | ALDH1A1HPGDPTGDR2ESR1ESR2 | |
| SCHEMBL8574316 | 0.71 | ESR1 (0.43) | F2PRSS1ESR1ESR2 | |
| SCHEMBL10558473 | 0.71 | F2 (0.34) | F2PRSS1PTGDR2ESR1ESR2 | |
| SCHEMBL10697596 | 0.69 | KDM1A (0.39) | PTGDR2 | |
| SCHEMBL21311988 | 0.68 | ESR1 (0.40) | F2PRSS1ESR1ESR2CHRM1 | |
| SCHEMBL21400399 | 0.68 | ABCB1 (0.44) | F2PRSS1ESR1ESR2CHRM1 | |
| SCHEMBL9672580 | 0.68 | POLB (0.49) | ALDH1A1HPGDPTGDR2POLBMAPT | |
| SCHEMBL10494051 | 0.68 | POLB (0.49) | ALDH1A1HPGDPTGDR2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275603-A1 | Tricyclic 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-07-27 | — | — | EP | disclosed |