Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 2/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698420 | 0.97 | PPIA (0.52) | PPIAPTGDR2ESR1ESR2POLB | |
| SCHEMBL10407009 | 0.85 | PPIA (0.46) | PPIAESR1ESR2ALDH1A1HPGD | |
| SCHEMBL10697596 | 0.83 | KDM1A (0.39) | PPIAPTGDR2KDM1AMAOB | |
| SCHEMBL10408026 | 0.82 | PPIA (0.49) | PPIAPTGDR2ALDH1A1HPGD | |
| SCHEMBL10698703 | 0.74 | ALDH1A1 (0.37) | PTGDR2ESR1ESR2POLBALDH1A1 | |
| SCHEMBL10408027 | 0.74 | ALDH1A1 (0.37) | PTGDR2ESR1ESR2POLBALDH1A1 | |
| SCHEMBL9820926 | 0.73 | PPIA (0.45) | PPIAALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9820718 | 0.72 | PPIA (0.44) | PPIAALDH1A1MEN1KMT2A | |
| SCHEMBL10699741 | 0.71 | PTGDR2 (0.42) | PPIAPTGDR2ALDH1A1HPGDKDM1A | |
| SCHEMBL10703795 | 0.71 | RBP4 (0.40) | PTGDR2ALDH1A1HPGDKDM1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275603-A1 | Tricyclic 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-07-27 | — | — | EP | disclosed |