Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591609 | 0.91 | LMNA (0.56) | LMNADDB1CRBNGID4HTR2C | |
| SCHEMBL3591606 | 0.91 | LMNA (0.56) | LMNADDB1CRBNGID4HTR2C | |
| SCHEMBL10570984 | 0.82 | MAOB (0.47) | LMNADDB1CRBNCYP19A1MEN1 | |
| SCHEMBL9733035 | 0.82 | MAOB (0.47) | LMNADDB1CRBNCYP19A1MEN1 | |
| SCHEMBL2743638 | 0.81 | HSD11B1 (0.46) | HTR2CCYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL8022157 | 0.77 | MAOB (0.45) | LMNADDB1CRBNCYP19A1NPC1 | |
| SCHEMBL2743656 | 0.76 | TSHR (0.43) | CYP19A1KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL28354123 | 0.76 | TSHR (0.43) | CYP19A1KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL4440921 | 0.76 | HTR2C (0.50) | LMNADDB1CRBNGID4HTR2C | |
| SCHEMBL30949069 | 0.76 | HTR2C (0.50) | LMNADDB1CRBNGID4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271287-A2 | Quinoline dioic acids and amides | MERCK FROSST CANADA INC. (CA) | 1988-06-15 | — | — | EP | disclosed |