Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699997 | 0.88 | MAPT (0.51) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10693972 | 0.88 | NPC1 (0.41) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL10708879 | 0.88 | MAPT (0.52) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10709164 | 0.88 | MAPT (0.52) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10699998 | 0.87 | MAPT (0.49) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10708976 | 0.87 | MAPT (0.54) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10532755 | 0.86 | MAPT (0.52) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10701527 | 0.86 | MAPT (0.49) | MAPTNPC1MEN1KMT2AABCB1 | |
| SCHEMBL10698400 | 0.83 | MAPT (0.47) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL10530615 | 0.83 | MAPT (0.52) | MAPTNPC1ABCB1ABCC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |