Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698788 | 0.88 | MAPT (0.55) | NPC1RAB9AKMT2APOLBMAPT | |
| SCHEMBL10698083 | 0.87 | NPC1 (0.40) | NPC1RAB9AMCL1WDR5KMT2A | |
| SCHEMBL10699685 | 0.87 | NPC1 (0.39) | NPC1RAB9AMCL1WDR5KMT2A | |
| SCHEMBL10695938 | 0.86 | MAPT (0.52) | NPC1RAB9AKMT2APOLBMAPT | |
| SCHEMBL10697943 | 0.86 | MAPT (0.41) | NPC1RAB9AMCL1WDR5KMT2A | |
| SCHEMBL10532556 | 0.85 | WDR5 (0.39) | NPC1RAB9AMCL1WDR5KMT2A | |
| SCHEMBL10698960 | 0.85 | MAPT (0.41) | NPC1RAB9AMCL1WDR5KMT2A | |
| SCHEMBL10698512 | 0.83 | MAPT (0.43) | NPC1RAB9AMCL1KMT2APOLB | |
| SCHEMBL10698400 | 0.83 | MAPT (0.47) | NPC1RAB9AKMT2APOLBMAPT | |
| SCHEMBL10698508 | 0.82 | MAPT (0.53) | NPC1RAB9AKMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |