Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 10/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 5/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697238 | 0.95 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL10698573 | 0.87 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL10695099 | 0.86 | MEN1 (0.48) | CYP11B1CYP11B2KITATMBMPR1B | |
| SCHEMBL10699542 | 0.84 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL10697875 | 0.83 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL10698954 | 0.81 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL10691731 | 0.80 | TRIM24 (0.44) | BMPR1BBMPR1AACVRL1ACVR1TRIM24 | |
| SCHEMBL10701774 | 0.78 | TRIM24 (0.43) | CYP11B1CYP11B2CYP1A2TRIM24 | |
| SCHEMBL10697210 | 0.78 | CA12 (0.51) | CYP19A1TRIM24 | |
| SCHEMBL10695333 | 0.76 | ALDH1A1 (0.55) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |