Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 6/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | PYGM | P11217 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12992155 | 0.80 | MAPT (0.51) | MAPTHPGDAADATCYP19A1ACHE | |
| SCHEMBL18569594 | 0.75 | MAPT (0.52) | MAPTHPGDSRD5A1AADATACHE | |
| SCHEMBL28250154 | 0.73 | ACHE (0.53) | MAPTHPGDSRD5A1ACHEPYGL | |
| SCHEMBL9560256 | 0.71 | MAPT (0.56) | MAPTHPGDAADATACHEPYGL | |
| SCHEMBL6603228 | 0.71 | ACHE (0.55) | MAPTHPGDAADATACHEPYGL | |
| SCHEMBL27251645 | 0.71 | MAPT (0.59) | MAPTHPGDSRD5A1KDM4E | |
| SCHEMBL2202325 | 0.71 | GAA (0.33) | MAPTKDM4EGAAMAPK1HTT | |
| SCHEMBL6604704 | 0.70 | ALDH1A1 (0.49) | MAPTHPGDACHEKDM4EGAA | |
| SCHEMBL12991752 | 0.70 | MAPT (0.62) | MAPTHPGDKDM4EGAA | |
| SCHEMBL10521184 | 0.67 | MAPT (0.51) | MAPTHPGDAADATACHEPYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |