Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698951 | 0.88 | MAPT (0.52) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10695333 | 0.84 | ALDH1A1 (0.55) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10698699 | 0.83 | TOP1 (0.44) | ALDH1A1HPGDSMN1; SMN2HSD17B10BMPR1B | |
| SCHEMBL10534922 | 0.82 | MAPT (0.47) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10700944 | 0.81 | CBFB (0.54) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10701672 | 0.78 | MAPT (0.48) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10697571 | 0.78 | MAPT (0.48) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10698954 | 0.76 | CYP11B1 (0.48) | MAPTCYP11B1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL10698172 | 0.75 | RHEB (0.49) | MAPTALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL10532390 | 0.74 | MAPT (0.46) | MAPTALDH1A1KDM4EHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |