Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699429 | 0.88 | TOP1 (0.45) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10697404 | 0.88 | TOP1 (0.44) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10698920 | 0.83 | MAPT (0.50) | ALDH1A1HPGDSMN1; SMN2HSD17B10BMPR1B | |
| SCHEMBL10530395 | 0.80 | TOP1 (0.42) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10700944 | 0.80 | CBFB (0.54) | ALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10699532 | 0.77 | SLC2A1 (0.47) | ALDH1A1HPGDSMN1; SMN2HSD17B10NPBWR1 | |
| SCHEMBL10697738 | 0.77 | SCD (0.42) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10699139 | 0.77 | AURKB (0.47) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10698172 | 0.76 | RHEB (0.49) | ALDH1A1HPGDHSD17B10SCDGUSB | |
| SCHEMBL10702791 | 0.74 | BMPR1B (0.42) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |