Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10667809 | 0.98 | LMNA (0.59) | LMNAMAPTKDM4ECYP3A4HTT | |
| Bromide SCHEMBL10699147 | 0.97 | LMNA (0.58) | LMNAMAPTKDM4ECYP3A4HTT | |
| Iodide SCHEMBL10638043 | 0.76 | LMNA (0.96) | LMNAMAPTKDM4ECYP3A4HTT | |
| SCHEMBL4858817 | 0.76 | LMNA (0.96) | LMNAMAPTKDM4ECYP3A4HTT | |
| SCHEMBL9837615 | 0.76 | MAPT (0.67) | LMNAMAPTKDM4ECYP3A4HTT | |
| SCHEMBL9051161 | 0.76 | LMNA (0.96) | LMNAMAPTKDM4ECYP3A4HTT | |
| SCHEMBL1727666 | 0.75 | KDM4E (0.52) | KDM4ECYP1A2 | |
| SCHEMBL30951595 | 0.75 | KDM4E (0.52) | KDM4ECYP1A2 | |
| SCHEMBL21614330 | 0.74 | CCR1 (0.64) | LMNAMAPTKDM4ECYP3A4HTT | |
| SCHEMBL8313 | 0.74 | LMNA (1.00) | LMNAMAPTKDM4ECYP3A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260642-A2 | Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1988-03-23 | — | — | EP | disclosed |