Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699332 | 1.00 | MAOB (0.50) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL10696978 | 0.93 | MMP2 (0.53) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL10696967 | 0.93 | MMP2 (0.53) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL702346 | 0.79 | TAS1R3 (0.71) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL702347 | 0.79 | TAS1R3 (0.71) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL10699339 | 0.78 | TAS1R3 (0.55) | PTGS2LMNAHPGDHDAC3HDAC1 | |
| SCHEMBL9576093 | 0.78 | TAS1R3 (0.55) | PTGS2LMNAHPGDHDAC3HDAC1 | |
| SCHEMBL1559044 | 0.76 | SMN1; SMN2 (0.71) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL31440320 | 0.76 | SMN1; SMN2 (0.71) | MAOBAKR1B10AKR1B1PTGS2GLO1 | |
| SCHEMBL1557401 | 0.76 | SMN1; SMN2 (0.71) | MAOBAKR1B10AKR1B1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274546-A1 | New oxazolinone compounds useful as intermediates for the preparation of insecticidal and acaracidal cinnamide compounds | AMERICAN CYANAMID COMPANY (US) | 1988-07-20 | — | — | EP | claimed |
| EP-0274546-A1 | New oxazolinone compounds useful as intermediates for the preparation of insecticidal and acaracidal cinnamide compounds | AMERICAN CYANAMID COMPANY (US) | 1988-07-20 | — | — | EP | disclosed |