Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697132 | 0.90 | NPC1 (0.48) | CA12CA9NPC1RAB9AMEN1 | |
| SCHEMBL10707505 | 0.89 | CA12 (0.44) | CA12CA9NPC1RAB9AMEN1 | |
| SCHEMBL10698542 | 0.86 | CA12 (0.44) | CA12CA9NPC1RAB9AMEN1 | |
| SCHEMBL10694340 | 0.85 | CA12 (0.50) | CA12CA9NPC1RAB9AMEN1 | |
| SCHEMBL10701679 | 0.82 | MEN1 (0.41) | CA12CA9NPC1RAB9AHDAC1 | |
| SCHEMBL10697886 | 0.81 | CYP11B1 (0.47) | MEN1KMT2ADHFR | |
| SCHEMBL10699273 | 0.81 | DHODH (0.39) | CA12CA9NPC1RAB9AHDAC1 | |
| SCHEMBL10698199 | 0.79 | CA12 (0.46) | CA12CA9NPC1RAB9AHDAC1 | |
| SCHEMBL10699478 | 0.78 | MEN1 (0.41) | CA12CA9NPC1RAB9AHDAC1 | |
| SCHEMBL10699035 | 0.78 | CA12 (0.45) | CA12CA9NPC1RAB9AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |