Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389197 | 0.86 | GPR119 (0.53) | GPR119S1PR1TBK1 | |
| SCHEMBL4263363 | 0.77 | GPR119 (0.51) | GPR119TBK1 | |
| SCHEMBL5889155 | 0.77 | GPR119 (0.53) | GPR119TGFBR1TBK1 | |
| SCHEMBL27747830 | 0.76 | GPR119 (0.49) | GPR119TGFBR1TBK1 | |
| SCHEMBL4721764 | 0.76 | S1PR1 (0.45) | GPR119S1PR1TBK1MEN1KMT2A | |
| SCHEMBL389462 | 0.76 | GPR119 (0.53) | GPR119TGFBR1TBK1KMT2A | |
| SCHEMBL27734776 | 0.75 | GPR119 (0.48) | GPR119TGFBR1TBK1 | |
| SCHEMBL388123 | 0.75 | S1PR1 (0.48) | GPR119S1PR1TBK1 | |
| SCHEMBL5603661 | 0.74 | GPR119 (0.47) | GPR119TGFBR1TBK1 | |
| SCHEMBL386691 | 0.74 | GPR119 (0.56) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |