Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389197 | 0.90 | GPR119 (0.53) | S1PR1GPR119TBK1SYK | |
| SCHEMBL4765477 | 0.89 | GPR119 (0.40) | GPR119TBK1FGFR3KMT2ALCK | |
| SCHEMBL4719145 | 0.88 | S1PR1 (0.47) | S1PR1GPR119TBK1FGFR3LCK | |
| SCHEMBL4720368 | 0.87 | S1PR1 (0.39) | S1PR1GPR119TBK1FGFR3LCK | |
| SCHEMBL4721914 | 0.85 | GPR119 (0.46) | S1PR1GPR119TBK1 | |
| SCHEMBL4721660 | 0.84 | GPR119 (0.40) | S1PR1GPR119TBK1FGFR3JAK2 | |
| SCHEMBL4721883 | 0.84 | CDK1 (0.40) | S1PR1GPR119TBK1FGFR3ABL1 | |
| SCHEMBL4721012 | 0.84 | TBK1 (0.38) | S1PR1GPR119TBK1FGFR3LCK | |
| SCHEMBL4719783 | 0.83 | TBK1 (0.39) | S1PR1GPR119TBK1FGFR3LCK | |
| SCHEMBL4719878 | 0.83 | TNNI3K (0.41) | S1PR1GPR119TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |